deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution

20161,314 citationsJournal Articlegold Open Access

Authors

Rachel Rosenthal · The Honourable Society of Lincoln's Inn

Nicholas McGranahan · CRUK Lung Cancer Centre of Excellence

Javier Herrero · CRUK Lung Cancer Centre of Excellence

Barry S. Taylor · Molecular Oncology (United States)

Charles Swanton · The Francis Crick Institute

Abstract

deconstructSigs confers the ability to define mutational processes driven by environmental exposures, DNA repair abnormalities, and mutagenic processes in individual tumors with implications for precision cancer medicine.

Topics & Keywords

Cancer Genomics and Diagnostics Genetic factors in colorectal cancer DNA Repair Mechanisms

UN Sustainable Development Goals

Life in Land

Publication Details

Published in: Genome biology

Volume 17, Issue 1, pp. 31-31

DOI: 10.1186/s13059-016-0893-4

Field-Weighted Citation Impact: 40.98