CBFB-MYH11 hypomethylation signature and PBX3 differential methylation revealed by targeted bisulfite sequencing in patients with acute myeloid leukemia

201412 citationsJournal Articlegold Open Access

Authors

H Hájková · Institute of Haematology and Blood Transfusion

Markus Hsi-Yang Fritz · European Molecular Biology Laboratory

C Haškovec · Institute of Haematology and Blood Transfusion

Jiřı́ Schwarz · Institute of Haematology and Blood Transfusion

Cyril Šálek · Institute of Haematology and Blood Transfusion

Jana Marková · Institute of Haematology and Blood Transfusion

Zdeněk Krejčík

Abstract

We discovered new genomic regions with aberrant DNA methylation that are associated with expression of genes involved in leukemogenesis. Our results demonstrate the potential of the targeted approach for DNA methylation studies to reveal new regulatory regions.

Topics & Keywords

Acute Myeloid Leukemia Research Epigenetics and DNA Methylation Cancer-related gene regulation

Publication Details

Published in: Journal of Hematology & Oncology

Volume 7, Issue 1, pp. 66-66

DOI: 10.1186/s13045-014-0066-4

Field-Weighted Citation Impact: 1.16

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CBFB-MYH11 hypomethylation signature and PBX3 differential methylation revealed by targeted bisulfite sequencing in patients with acute myeloid leukemia

Authors

Abstract

Topics & Keywords

Publication Details