Association of Proton Pump Inhibitors With Risk of Dementia

2016551 citationsJournal Articlebronze Open Access

Authors

Willy Gomm · German Center for Neurodegenerative Diseases

Klaus von Holt · German Center for Neurodegenerative Diseases

Friederike Thomé · German Center for Neurodegenerative Diseases

Karl Broich · Federal Institute for Drugs and Medical Devices

Wolfgang Maier · German Center for Neurodegenerative Diseases

Anne Fink · German Center for Neurodegenerative Diseases

Gabriele Doblhammer

Abstract

The avoidance of PPI medication may prevent the development of dementia. This finding is supported by recent pharmacoepidemiological analyses on primary data and is in line with mouse models in which the use of PPIs increased the levels of β-amyloid in the brains of mice. Randomized, prospective clinical trials are needed to examine this connection in more detail.

Topics & Keywords

Gastroesophageal reflux and treatments Helicobacter pylori-related gastroenterology studies Esophageal and GI Pathology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA Neurology

Volume 73, Issue 4, pp. 410-410

DOI: 10.1001/jamaneurol.2015.4791

Field-Weighted Citation Impact: 71.78