Galectin-3 Plays an Important Pro-inflammatory Role in the Induction Phase of Acute Colitis by Promoting Activation of NLRP3 Inflammasome and Production of IL-1β in Macrophages

2016129 citationsJournal Articlebronze Open Access

Authors

Bojana Simović Marković · University of Kragujevac

Aleksandar Nikolić · University of Kragujevac

Marina Gazdic · University of Kragujevac

Sanja Bojić · University of Kragujevac

Ljubica Vučićević · University of Belgrade

Milica Kosić · University of Belgrade

Slobodanka Mitrović ·

Abstract

Gal-3 expression promotes acute DSS-induced colitis and plays an important pro-inflammatory role in the induction phase of colitis by promoting the activation of NLRP3 inflammasome and production of IL-1β in macrophages.

Topics & Keywords

Galectins and Cancer Biology Macrophage Migration Inhibitory Factor Peptidase Inhibition and Analysis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Crohn s and Colitis

Volume 10, Issue 5, pp. 593-606

DOI: 10.1093/ecco-jcc/jjw013

Field-Weighted Citation Impact: 5.44