Effect of chenodeoxycholic acid and the bile acid sequestrant colesevelam on glucagon‐like peptide‐1 secretion

201692 citationsJournal Articlegreen Open Access

Authors

Mette Hansen · University of Copenhagen

Matthijs J. Scheltema · Amsterdam University Medical Centers

David P. Sonne · University of Copenhagen

Jakob S. Hansen · Copenhagen University Hospital

M. Sperling · Gentofte Hospital

Jens F. Rehfeld · Rigshospitalet

Jens J. Holst ·

Abstract

CDCA increased GLP-1 and glucagon secretion, and delayed gastric emptying. We speculate that bile acid-induced activation of TGR5 on L cells increases GLP-1 secretion, which, in turn, may result in amplification of glucose-stimulated insulin secretion. Furthermore our data suggest that colesevelam does not have an acute effect on GLP-1 secretion in humans.

Topics & Keywords

Drug Transport and Resistance Mechanisms Diabetes Treatment and Management Neuropeptides and Animal Physiology

Publication Details

Published in: Diabetes Obesity and Metabolism

Volume 18, Issue 6, pp. 571-580

DOI: 10.1111/dom.12648

Field-Weighted Citation Impact: 6.31

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Effect of chenodeoxycholic acid and the bile acid sequestrant colesevelam on glucagon‐like peptide‐1 secretion

Authors

Abstract

Topics & Keywords

Publication Details