Adipose tissue fibrosis, hypertrophy, and hyperplasia: Correlations with diabetes in human obesity

2016354 citationsJournal Article

Authors

Lindsey A. Muir · University of Michigan–Ann Arbor

Christopher K. Neeley · University of Michigan–Ann Arbor

Kevin A. Meyer · University of Michigan–Ann Arbor

Nicki A. Baker · University of Michigan–Ann Arbor

Alice M. Brosius · University of Michigan–Ann Arbor

Alexandra R. Washabaugh · University of Michigan–Ann Arbor

Oliver A. Varban

Abstract

These data are consistent with the hypothesis that adipose tissue fibrosis in the context of human obesity limits adipocyte hypertrophy and is associated with a reciprocal increase in adipocyte hyperplasia, with beneficial effects on systemic metabolism. These findings suggest adipose tissue fibrosis as a potential target for manipulation of adipocyte metabolism.

Topics & Keywords

Adipokines, Inflammation, and Metabolic Diseases Cardiovascular Disease and Adiposity Adipose Tissue and Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Obesity

Volume 24, Issue 3, pp. 597-605

DOI: 10.1002/oby.21377

Field-Weighted Citation Impact: 19.31