Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals

2015779 citationsJournal Article

Authors

Joshua R. Dunetz · Gilead Sciences (United States)

Gerald A. Weisenburger · Pfizer (United States)

Abstract

This review showcases various coupling reagents which have been implemented specifically for large-scale amide synthesis via the condensation of an acid and amine, while highlighting the benefits and drawbacks of each reagent on an industrial scale.

Topics & Keywords

Chemical Synthesis and Analysis Advanced Synthetic Organic Chemistry Chemical synthesis and alkaloids

UN Sustainable Development Goals

Industry, innovation and infrastructure

Publication Details

Published in: Organic Process Research & Development

Volume 20, Issue 2, pp. 140-177

DOI: 10.1021/op500305s

Field-Weighted Citation Impact: 19.02