Phenyltrimethylammonium Salts as Methylation Reagents in the Nickel‐Catalyzed Methylation of C−H Bonds

2016143 citationsJournal Article

Authors

Takeshi Uemura · Museum of Japanese Art Yamato Bunkakan

Mao Yamaguchi · Museum of Japanese Art Yamato Bunkakan

Abstract

Methylation of C(sp(2))-H bonds was achieved through the Ni(II)-catalyzed reaction of benzamides with phenyltrimethylammonium bromide or iodide as the source of the methyl group. The reaction has a broad scope and shows high functional-group compatibility. The reaction is also applicable to the methylation of C(sp(3))-H bonds in aliphatic amides.

Topics & Keywords

Catalytic C–H Functionalization Methods Synthesis and Catalytic Reactions Asymmetric Hydrogenation and Catalysis

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Angewandte Chemie International Edition

Volume 55, Issue 9, pp. 3162-3165

DOI: 10.1002/anie.201511197

Field-Weighted Citation Impact: 17.83