Chaperonin Containing TCP-1 Protein Level in Breast Cancer Cells Predicts Therapeutic Application of a Cytotoxic Peptide

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Authors

Rania Bassiouni · University of Central Florida

Kathleen N. Nemec · University of Central Florida

Ashley Iketani · University of Central Florida

Orielyz Flores · University of Central Florida

Anne Showalter · University of Central Florida

Amr S. Khaled · University of Central Florida

Priya Vishnubhotla

Abstract

Increased CCT protein in breast cancer cells underlies the cytotoxicity of CT20p. CCT is thus a potential target for therapeutic intervention and serves as a companion diagnostic to personalize the therapeutic use of CT20p for breast cancer treatment. Clin Cancer Res; 22(17); 4366-79. ©2016 AACR.

Topics & Keywords

Heat shock proteins research Protein Structure and Dynamics Computational Drug Discovery Methods

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 22, Issue 17, pp. 4366-4379

DOI: 10.1158/1078-0432.ccr-15-2502

Field-Weighted Citation Impact: 2.44