CTCF-mediated chromatin loops enclose inducible gene regulatory domains

201668 citationsJournal Articlegold Open Access

Authors

Martin Oti · Radboud Institute for Molecular Life Sciences

Jonas Falck · Radboud Institute for Molecular Life Sciences

Martijn A. Huynen · Radboud University Medical Center

Huiqing Zhou · Radboud University Nijmegen

Abstract

We provide computational evidence that CTCF-mediated chromatin interactions enclose domains of stimulus responsive enhancer-regulated genes, insulating them from nearby housekeeping genes.

Topics & Keywords

Genomics and Chromatin Dynamics Genomic variations and chromosomal abnormalities Epigenetics and DNA Methylation

Publication Details

Published in: BMC Genomics

Volume 17, Issue 1, pp. 252-252

DOI: 10.1186/s12864-016-2516-6

Field-Weighted Citation Impact: 5.92

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CTCF-mediated chromatin loops enclose inducible gene regulatory domains

Authors

Abstract

Topics & Keywords

Publication Details