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ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTCopper Active Sites in BiologyEdward I. Solomon*, David E. Heppner, Esther M. Johnston, Jake W. Ginsbach, Jordi Cirera, Munzarin Qayyum, Matthew T. Kieber-Emmons, Christian H. Kjaergaard, Ryan G. Hadt, and Li TianView Author Information Department of Chemistry, Stanford University, Stanford, California 94305, United States*E-mail: [email protected]Cite this: Chem. Rev. 2014, 114, 7, 3659–3853Publication Date (Web):March 3, 2014Publication History Received17 June 2013Published online3 March 2014Published inissue 9 April 2014https://pubs.acs.org/doi/10.1021/cr400327thttps://doi.org/10.1021/cr400327treview-articleACS PublicationsCopyright © 2014 American Chemical SocietyRequest reuse permissionsArticle Views32519Altmetric-Citations1308LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Copper,Crystal structure,Ligands,Peptides and proteins,Redox reactions Get e-Alerts