Pathophysiology of Premature Skin Aging Induced by Ultraviolet Light

19971,471 citationsJournal Articlebronze Open Access

Authors

Gary J. Fisher · University of Michigan

ZengQuan Wang · University of Michigan

Subhash C. Datta · University of Michigan

James Varani · University of Michigan

Sewon Kang · University of Michigan

John J. Voorhees · University of Michigan

Abstract

Multiple exposures to ultraviolet irradiation lead to sustained elevations of matrix metalloproteinases that degrade skin collagen and may contribute to photoaging. Treatment with topical tretinoin inhibits irradiation-induced matrix metalloproteinases but not their endogenous inhibitor.

Topics & Keywords

Skin Protection and Aging Antioxidant Activity and Oxidative Stress Dermatologic Treatments and Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 337, Issue 20, pp. 1419-1429

DOI: 10.1056/nejm199711133372003

Field-Weighted Citation Impact: 31.64