Limited immune restoration after 3 years’ suppression of HIV-1 replication in patients with moderately advanced disease

2002210 citationsJournal Article

Authors

Hernán Valdez · Cornell University

Elizabeth Connick · Cornell University

Kimberly Y. Smith · Cornell University

Michael M. Lederman · Cornell University

Ronald J. Bosch · Cornell University

Ryung S. Kim · Cornell University

Marty St. Clair ·

Abstract

Immune restoration was incomplete in patients who started HAART with moderately advanced HIV-1 disease and most changes occurred during the first year. These data suggest that this degree of suppression of HIV-1 replication alone will not suffice to restore immune competence. The clinical significance of incomplete reconstitution of CD4 lymphocyte number, phenotype, and proliferative function in HIV-1 infection remains to be determined.

Topics & Keywords

HIV Research and Treatment HIV/AIDS Research and Interventions Cytomegalovirus and herpesvirus research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: AIDS

Volume 16, Issue 14, pp. 1859-1866

DOI: 10.1097/00002030-200209270-00002

Field-Weighted Citation Impact: 4.82