A Short-Term Trial of Butyrate to Stimulate Fetal-Globin-Gene Expression in the β-Globin Disorders

1993444 citationsJournal Articlebronze Open Access

Authors

Susan P. Perrine

Gordon D. Ginder · University of Minnesota

Douglas V. Faller · Boston University

George Dover · Johns Hopkins Medicine

Tohru Ikuta · University of California, San Francisco

H. Ewa Witkowska

Shi‐Ping Cai · University of California, San Francisco

Elliott Vichinsky

Abstract

In patients with beta-hemoglobinopathies butyrate, a natural fatty acid, can significantly and rapidly increase fetal-globin production to levels that can ameliorate beta-globin disorders. Further trials of this class of compounds are warranted to determine long-term tolerance and efficacy in patients with sickle cell anemia or beta-thalassemia.

Topics & Keywords

Hemoglobinopathies and Related Disorders Iron Metabolism and Disorders Prenatal Screening and Diagnostics

Publication Details

Published in: New England Journal of Medicine

Volume 328, Issue 2, pp. 81-86

DOI: 10.1056/nejm199301143280202

Field-Weighted Citation Impact: 21.23

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A Short-Term Trial of Butyrate to Stimulate Fetal-Globin-Gene Expression in the β-Globin Disorders

Authors

Abstract

Topics & Keywords

Publication Details