Irinotecan plus Fluorouracil and Leucovorin for Metastatic Colorectal Cancer

20003,003 citationsJournal Articlebronze Open Access

Authors

Leonard B. Saltz · Memorial Sloan Kettering Cancer Center

John V. Cox · Texas Oncology

Charles D. Blanke

Lee S. Rosen · UCLA Medical Center

Louis Fehrenbacher

Malcolm J. Moore · Princess Margaret Hospital

Jean A. Maroun · Ottawa Regional Cancer Foundation

Stephen P. Ackland

Abstract

Weekly treatment with irinotecan plus fluorouracil and leucovorin is superior to a widely used regimen of fluorouracil and leucovorin for metastatic colorectal cancer in terms of progression-free survival and overall survival.

Topics & Keywords

Colorectal Cancer Treatments and Studies Colorectal and Anal Carcinomas Hepatocellular Carcinoma Treatment and Prognosis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 343, Issue 13, pp. 905-914

DOI: 10.1056/nejm200009283431302

Field-Weighted Citation Impact: 78.37