Reconstitution of Cellular Immunity against Cytomegalovirus in Recipients of Allogeneic Bone Marrow by Transfer of T-Cell Clones from the Donor

19951,792 citationsJournal Article

Authors

Elizabeth Walter · University of Washington

Philip D. Greenberg · Fred Hutch Cancer Center

M. Jean Gilbert · Fred Hutch Cancer Center

Rosalynde J. Finch · University of Washington

Käthe S. Watanabe · Fred Hutch Cancer Center

E. Donnall Thomas · Fred Hutch Cancer Center

Stanley R. Riddell

Abstract

The transfer of CMV-specific clones of CD8+ T cells derived from the bone marrow donor is a safe and effective way to reconstitute cellular immunity against CMV after allogeneic marrow transplantation.

Topics & Keywords

Cytomegalovirus and herpesvirus research Hematopoietic Stem Cell Transplantation Herpesvirus Infections and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 333, Issue 16, pp. 1038-1044

DOI: 10.1056/nejm199510193331603

Field-Weighted Citation Impact: 45.91