Lack of Effect of Long-Term Supplementation with Beta Carotene on the Incidence of Malignant Neoplasms and Cardiovascular Disease

19962,407 citationsJournal Articlebronze Open Access

Authors

Charles H. Hennekens · Harvard University

Julie E. Buring · Harvard University

JoAnn E. Manson · Brigham and Women's Hospital

Meir J. Stampfer · Harvard University

Bernard Rosner · Brigham and Women's Hospital

Nancy R. Cook · Harvard University

Charlene Belanger ·

Abstract

In this trial among healthy men, 12 years of supplementation with beta carotene produced neither benefit nor harm in terms of the incidence of malignant neoplasms, cardiovascular disease, or death from all causes.

Topics & Keywords

Antioxidant Activity and Oxidative Stress Cancer, Lipids, and Metabolism Retinoids in leukemia and cellular processes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 334, Issue 18, pp. 1145-1149

DOI: 10.1056/nejm199605023341801

Field-Weighted Citation Impact: 65.86