Systematic identification of genetic influences on methylation across the human life course

2016645 citationsJournal Articlegold Open Access

Authors

Tom R. Gaunt · University of Bristol

Hashem A. Shihab · University of Bristol

Gibran Hemani · University of Bristol

Josine L. Min · University of Bristol

Geoff Woodward · University of Bristol

Oliver Lyttleton · University of Bristol

Jie Zheng ·

Abstract

DNA methylation contains a significant heritable component that remains consistent across the lifespan. Our results suggest that the genetic component of methylation may have a causal role in complex traits. The database of mQTL presented here provide a rich resource for those interested in investigating the role of methylation in disease.

Topics & Keywords

Epigenetics and DNA Methylation Birth, Development, and Health Genetic Associations and Epidemiology

Publication Details

Published in: Genome biology

Volume 17, Issue 1, pp. 61-61

DOI: 10.1186/s13059-016-0926-z

Field-Weighted Citation Impact: 38.72

Command Palette

Systematic identification of genetic influences on methylation across the human life course

Authors

Abstract

Topics & Keywords

Publication Details