Ursodeoxycholic Acid Attenuates Acute Aortic Dissection Formation in Angiotensin II-Infused Apolipoprotein E-Deficient Mice Associated with Reduced ROS and Increased Nrf2 Levels

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Authors

Wanjun Liu · Huazhong University of Science and Technology

Bei Wang · Tongji Hospital

Tao Wang · Tongji Hospital

Xintian Liu · Tongji Hospital

Xingwei He · Huazhong University of Science and Technology

Yujian Liu · Huazhong University of Science and Technology

Zhuxi Li ·

Abstract

These results demonstrate that UDCA prevented AAD formation by reducing apoptosis of VSMCs caused by oxidative stress in Nrf2 dependent manner and suggest that UDCA might have clinical potential to suppress AAD formation.

Topics & Keywords

Aortic aneurysm repair treatments Aortic Disease and Treatment Approaches Macrophage Migration Inhibitory Factor

Publication Details

Published in: Cellular Physiology and Biochemistry

Volume 38, Issue 4, pp. 1391-1405

DOI: 10.1159/000443082

Field-Weighted Citation Impact: 3.84

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Ursodeoxycholic Acid Attenuates Acute Aortic Dissection Formation in Angiotensin II-Infused Apolipoprotein E-Deficient Mice Associated with Reduced ROS and Increased Nrf2 Levels

Authors

Abstract

Topics & Keywords

Publication Details