Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis

20003,015 citationsJournal Articlebronze Open Access

Authors

Peter E. Lipsky · The University of Texas Southwestern Medical Center

Désirée van der Heijde · Maastricht University Medical Centre

E. William St. Clair

Daniel E. Fürst · Virginia Mason Medical Center

Ferdinand C. Breedveld · Leiden University

Joachim R. Kalden · Fraunhofer Institute for Cell Therapy and Immunology

Josef S Smolen · University of Vienna

Abstract

In patients with persistently active rheumatoid arthritis despite methotrexate therapy, repeated doses of infliximab in combination with methotrexate provided clinical benefit and halted the progression of joint damage.

Topics & Keywords

Rheumatoid Arthritis Research and Therapies Autoimmune and Inflammatory Disorders Research Systemic Lupus Erythematosus Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 343, Issue 22, pp. 1594-1602

DOI: 10.1056/nejm200011303432202

Field-Weighted Citation Impact: 120.13