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Numerous congenital anomalies of the gallbladder have been recorded and reviewed comprehensively by Gross in 1936 (1), Flannery in 1956 (2), and Rabinovitch in 1958 (3). Multiseptate gallbladder has been mentioned only rarely in the literature (4, 5), and no case has been described in any detail. The present report records the clinical, radiological, and pathological aspects of this unusual anomaly, complicated by mild chronic infection Case History Clinical Data: K. Y, a 32-year-old female , was admitted to the hospital because of upper abdominal and back pain of three weeks duration. Starting as a dull ache in the right upper quadrant of the abdomen, with some radiation to the back, the interscapular area, and the right shoulder, the pain persisted, its intensity varying from mild to moderate. Aspirin provided some relief. There were no specific precipitating or aggravating factors and no history of specific food intolerance could be obtained. Similar attacks of abdominal pain had occurred intermittently for seven years. System review was noncontributory. There were no associated nausea, vomiting, fever, jaundice, or itching. The patient appeared in good health and in no obvious discomfort. The temperature, pulse, respiration, and blood pressure were normal. There was no evidence of jaundice. There was diffuse abdominal tenderness, maximal in the right upper quadrant, with splinting of respiration. No intra-abdominal masses could be palpated. Bowel sounds were hyperactive. Otherwise physical examination was normal. Laboratory Investigation: Urine and stool examinations were normal. The hemoglobin was 16.0 gm. per cent; white blood cell count 7,900 per cubic millimeter, with normal differential count. Liver function tests, including serum bilirubin and alkaline phosphatase determinations, were within normal limits. Radiological Features: Plain films of the abdomen demonstrated no radiopaque biliary calculi. Oral cholecystography (Telepaque, 3.0 gm.) showed excellent concentration of the contrast medium in the gallbladder fourteen hours after its ingestion (Fig. 1,A). The size, position, and general configuration of the gallbladder were within normal limits. There was, however, a striking subdivision of the contrast medium by multiple, thin, criss-crossing septa, producing an irregular mosaic pattern. The overall appearance closely resembled a wrinkled dried prune. Twenty minutes after a fatty meal, there was satisfactory contraction of the gallbladder, with visualization of the cystic duct and the proximal part of the common bile duct (Fig. 1,B) . The cystic duct showed some septation. The common duct appeared normal. No biliary calculi could be identified in the gallbladder or major ducts. The radiologic appearances were identical with those of a similar examination performed four and one-half years earlier.