Cobalt-Catalyzed Hydrofluorination of Unactivated Olefins: A Radical Approach of Fluorine Transfer

2013159 citationsJournal Article

Authors

Abstract

Catalytic hydrofluorination of olefins using a cobalt catalyst was developed. The exclusive Markovnikov selectivity, functional group tolerance, and scalability of this reaction make it an attractive protocol for the hydrofluorination of olefins. A preliminary mechanistic experiment showed the involvement of a radical intermediate.

Topics & Keywords

Fluorine in Organic Chemistry Catalytic C–H Functionalization Methods Radical Photochemical Reactions

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Organic Letters

Volume 15, Issue 20, pp. 5158-5161

DOI: 10.1021/ol402696h

Field-Weighted Citation Impact: 7.30