Ce(SO4)2-catalysed the highly diastereoselective synthesis of tetrahydroquinolines via an imino Diels Alder ABB′ type reaction and their in vivo toxicity and imaging in zebrafish embryos

201620 citationsJournal Article

Authors

Carlos A. Martínez Bonilla · Corporación para el Desarrollo Sostenible del Urabá

Carlos E. Puerto Galvis · Industrial University of Santander

Leonor Y. Vargas Méndez · Universidad Autónoma de Bucaramanga

Vladímir V. Kouznetsov · Industrial University of Santander

Abstract

The synthesis of tetrahydroquinolines <italic>via</italic> the Povarov reaction has been developed using Ce(SO2)4 as a catalyst. This efficient protocol allowed the toxicity and phenotypic study of these products using a zebrafish embryo model.

Topics & Keywords

Synthesis and Catalytic Reactions Chemical Synthesis and Analysis Click Chemistry and Applications

Publication Details

Published in: RSC Advances

Volume 6, Issue 44, pp. 37478-37486

DOI: 10.1039/c6ra04325a

Field-Weighted Citation Impact: 2.87

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Ce(SO<sub>4</sub>)<sub>2</sub>-catalysed the highly diastereoselective synthesis of tetrahydroquinolines via an imino Diels Alder ABB′ type reaction and their in vivo toxicity and imaging in zebrafish embryos

Authors

Abstract

Topics & Keywords

Publication Details