Axonal Transection in the Lesions of Multiple Sclerosis

19984,033 citationsJournal Articlebronze Open Access

Authors

Bruce D. Trapp

John W. Peterson

Richard M. Ransohoff · Cerner (United States)

Richard A. Rudick · Cerner (United States)

Sverre Mørk · Haukeland University Hospital

Lars Bø

Abstract

Transected axons are common in the lesions of multiple sclerosis, and axonal transection may be the pathologic correlate of the irreversible neurologic impairment in this disease.

Topics & Keywords

Multiple Sclerosis Research Studies Neurogenesis and neuroplasticity mechanisms Peripheral Neuropathies and Disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 338, Issue 5, pp. 278-285

DOI: 10.1056/nejm199801293380502

Field-Weighted Citation Impact: 99.92