Langerhans'-Cell Histiocytosis (Histiocytosis X) -- A Clonal Proliferative Disease

19941,004 citationsJournal Articlebronze Open Access

Authors

Cheryl L. Willman · New Mexico Cancer Center

Lambert Busque · Harvard University

Barbara Griffith · University of New Mexico

Blaise E. Favara

Kenneth L. McClain · Baylor College of Medicine

Marilyn H. Duncan · University of New Mexico

D. Gary Gilliland · Brigham and Women's Hospital

Abstract

The detection of clonal histiocytes in all forms of Langerhans'-cell histiocytosis indicates that this disease is probably a clonal neoplastic disorder with highly variable biologic behavior. Thus, genetic mutations that promote clonal expansion of Langerhans' cells or their precursors may now be identified.

Topics & Keywords

Histiocytic Disorders and Treatments Herpesvirus Infections and Treatments RNA regulation and disease

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 331, Issue 3, pp. 154-160

DOI: 10.1056/nejm199407213310303

Field-Weighted Citation Impact: 21.69