Effect of 0.04% AR-13324, a ROCK, and Norepinephrine Transporter Inhibitor, on Aqueous Humor Dynamics in Normotensive Monkey Eyes

2013124 citationsJournal Article

Authors

Rongfang Wang · Icahn School of Medicine at Mount Sinai

Jennifer E. Williamson · Icahn School of Medicine at Mount Sinai

Casey Kopczynski · Aerie Pharmaceuticals (United States)

Janet B. Serle · Icahn School of Medicine at Mount Sinai

Abstract

AR-13324 reduces IOP in normotensive monkey eyes. A dual mechanism of action, increase in tonographic outflow facility, and decrease of aqueous humor flow rates, accounts for the IOP reduction in normotensive monkey eyes.

Topics & Keywords

Glaucoma and retinal disorders Retinal Development and Disorders Ocular Surface and Contact Lens

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Glaucoma

Volume 24, Issue 1, pp. 51-54

DOI: 10.1097/ijg.0b013e3182952213

Field-Weighted Citation Impact: 5.37