A Prospective Evaluation of an Angiotensin-Converting–Enzyme Gene Polymorphism and the Risk of Ischemic Heart Disease

1995910 citationsJournal Articlebronze Open Access

Authors

Klaus Lindpaintner · Children's Hospital

Marc A. Pfeffer

Reinhold Kreutz

Meir J. Stampfer · Brigham and Women's Hospital

Francine Grodstein · Brigham and Women's Hospital

F Lamotte · General Department of Preventive Medicine

Julie E. Buring · Harvard University

Charles H. Hennekens

Abstract

In a large, prospectively followed population of U.S. male physicians, the presence of the D allele of the ACE gene conferred no appreciable increase in the risk of ischemic heart disease or myocardial infarction.

Topics & Keywords

Renin-Angiotensin System Studies Genetic Associations and Epidemiology Hormonal Regulation and Hypertension

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 332, Issue 11, pp. 706-712

DOI: 10.1056/nejm199503163321103

Field-Weighted Citation Impact: 45.28