Utility of the Apolipoprotein E Genotype in the Diagnosis of Alzheimer's Disease

1998549 citationsJournal Articlebronze Open Access

Authors

Richard Mayeux · Nike (United States)

Ann M. Saunders

Steven Shea · Columbia University

Suzanne S. Mirra · Emory University

Denis A. Evans · Rush University Medical Center

Allen D. Roses

Bradley T. Hyman · Harvard University

Barbara J. Crain ·

Abstract

APOE genotyping does not provide sufficient sensitivity or specificity to be used alone as a diagnostic test for Alzheimer's disease, but when used in combination with clinical criteria, it improves the specificity of the diagnosis.

Topics & Keywords

Alzheimer's disease research and treatments Dementia and Cognitive Impairment Research Cholinesterase and Neurodegenerative Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 338, Issue 8, pp. 506-511

DOI: 10.1056/nejm199802193380804

Field-Weighted Citation Impact: 22.90