Omeprazole Compared with Misoprostol for Ulcers Associated with Nonsteroidal Antiinflammatory Drugs

1998862 citationsJournal Articlebronze Open Access

Authors

Christopher J. Hawkey · University of Nottingham

Jeffrey A. Karrasch · Peninsula Health

L Szczepański · Medical University of Lublin

Donald G. Walker

Alan Barkun · Montreal General Hospital

A J Swannell · Nottingham City Hospital

Neville D. Yeomans · University of Melbourne

Abstract

The overall rates of successful treatment of ulcers, erosions, and symptoms associated with NSAIDs were similar for the two doses of omeprazole and misoprostol. Maintenance therapy with omeprazole was associated with a lower rate of relapse than misoprostol. Omeprazole was better tolerated than misoprostol.

Topics & Keywords

Inflammatory mediators and NSAID effects Helicobacter pylori-related gastroenterology studies Drug-Induced Adverse Reactions

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 338, Issue 11, pp. 727-734

DOI: 10.1056/nejm199803123381105

Field-Weighted Citation Impact: 73.26