Acute heart failure with cardiomyocyte atrophy induced in adult mice by ablation of cardiac myosin light chain kinase

201636 citationsJournal Articlegreen Open Access

Authors

Michael T. Massengill · Florida College

Hassan Ashraf · University of Florida

Rajib Chowdhury · Florida College

Stephen M. Chrzanowski · Florida College

Jeena Kar · University of Florida

Sonisha Warren · University of Florida

Glenn A. Walter ·

Abstract

Our results, using a new mouse model mimicking an acute reduction of cMLCK, suggest that cMLCK plays a pivotal role in the transition from compensated to decompensated hypertrophy via sarcomeric disorganization.

Topics & Keywords

Cardiomyopathy and Myosin Studies Cardiac electrophysiology and arrhythmias Ion channel regulation and function

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cardiovascular Research

Volume 111, Issue 1, pp. 34-43

DOI: 10.1093/cvr/cvw069

Field-Weighted Citation Impact: 4.04