Trifluoromethylation of Alkenes by Visible Light Photoredox Catalysis

2012230 citationsJournal Article

Authors

Naeem Iqbal · Hanyang University

Sungkyu Choi · Hanyang University

Eun‐jin Kim · Hanyang University

Eun Jin Cho · Hanyang University

Abstract

A method for trifluoromethylation of alkenes has been developed employing visible light photoredox catalysis with CF(3)I, Ru(Phen)(3)Cl(2), and DBU. This process works especially well for terminal alkenes to give alkenyl-CF(3) products with only E-stereochemistry. The mild reaction conditions enable the trifluoromethylation of a range of alkenes that bear various functional groups.

Topics & Keywords

Fluorine in Organic Chemistry Inorganic Fluorides and Related Compounds Radical Photochemical Reactions

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: The Journal of Organic Chemistry

Volume 77, Issue 24, pp. 11383-11387

DOI: 10.1021/jo3022346

Field-Weighted Citation Impact: 14.71