A Controlled Clinical Trial of Dichloroacetate for Treatment of Lactic Acidosis in Adults

1992327 citationsJournal Articlebronze Open Access

Authors

Peter W. Stacpoole · The University of Texas Health Science Center at San Antonio

Elizabeth C. Wright · The University of Texas Health Science Center at San Antonio

Thomas G. Baumgartner · The University of Texas Health Science Center at San Antonio

Robert M. Bersin · The University of Texas Health Science Center at San Antonio

Scott E. Buchalter · The University of Texas Health Science Center at San Antonio

Stephen H. Curry · The University of Texas Health Science Center at San Antonio

Abstract

Dichloroacetate treatment of patients with severe lactic acidosis results in statistically significant but clinically unimportant changes in arterial-blood lactate concentrations and pH and fails to alter either hemodynamics or survival.

Topics & Keywords

Renal function and acid-base balance Respiratory Support and Mechanisms Gastroesophageal reflux and treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 327, Issue 22, pp. 1564-1569

DOI: 10.1056/nejm199211263272204

Field-Weighted Citation Impact: 6.24