Petrosal Sinus Sampling with and without Corticotropin-Releasing Hormone for the Differential Diagnosis of Cushing's Syndrome

1991867 citationsJournal Articlebronze Open Access

Authors

Edward H. Oldfield · National Institute of Neurological Disorders and Stroke

John L. Doppman · National Institutes of Health

Lynnette K. Nieman · National Institutes of Health

George P. Chrousos · National Institutes of Health

Donald L. Miller · National Institutes of Health

David A. Katz · National Institute of Neurological Disorders and Stroke

Gordon B. Cutler

Abstract

Simultaneous bilateral sampling of plasma from the inferior petrosal sinuses, with the adjunctive use of CRH, distinguishes patients with Cushing's disease from those with ectopic adrenocorticotropin secretion with high diagnostic accuracy.

Topics & Keywords

Pituitary Gland Disorders and Treatments Adrenal Hormones and Disorders Stress Responses and Cortisol

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 325, Issue 13, pp. 897-905

DOI: 10.1056/nejm199109263251301

Field-Weighted Citation Impact: 14.29