Renal Arteriography, Separate Renal-Function Studies and Renal Biopsy in Human Hypertension

THE production of experimental renal hypertension in animals, as a result of renal ischemia produced by constriction of one or both main renal arteries,1 has led to the recognition that in human beings, too, hypertension may result from ischemia of one or both kidneys, from any cause. In animals the blood pressure returns to normal as a result of the release of both constricting clamps, if the ischemia is bilateral, or as a result of the release of the clamp, or excision of the kidney, if only one main renal artery has been constricted, provided the other kidney is normal. . . .