Circulating microRNAs in Sera Correlate with Soluble Biomarkers of Immune Activation but Do Not Predict Mortality in ART Treated Individuals with HIV-1 Infection: A Case Control Study

20152,740 citationsJournal Articlegold Open Access

Authors

Daniel D. Murray · UNSW Sydney

Kazuo Suzuki · UNSW Sydney

Matthew Law · UNSW Sydney

Jonel Trebicka · University of Bonn

Jacquie Neuhaus · University of Minnesota

Deborah Wentworth · University of Minnesota

Margaret Johnson · Royal Free London NHS Foundation Trust

Abstract

No associations with mortality were found with any circulating miRNA studied. These results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection.

Topics & Keywords

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 10, Issue 10, pp. e0139981-e0139981

DOI: 10.1371/journal.pone.0139981

Field-Weighted Citation Impact: 343.15