Mutation of the Androgen-Receptor Gene in Metastatic Androgen-Independent Prostate Cancer

19951,250 citationsJournal Articlebronze Open Access

Authors

Mary‐Ellen Taplin · University of Massachusetts Chan Medical School

Glenn J. Bubley · Beth Israel Deaconess Hospital

Todd D. Shuster · Beth Israel Deaconess Hospital

Martha E. Frantz · Beth Israel Deaconess Hospital

Amy E. Spooner · Beth Israel Deaconess Hospital

George K. Ogata · Beth Israel Deaconess Hospital

Harold Keer

Abstract

Most metastatic androgen-independent prostate cancers express high levels of androgen-receptor gene transcripts. Mutations in androgen-receptor genes are not uncommon and may provide a selective growth advantage after androgen ablation.

Topics & Keywords

Prostate Cancer Treatment and Research Ubiquitin and proteasome pathways Sexual Differentiation and Disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 332, Issue 21, pp. 1393-1398

DOI: 10.1056/nejm199505253322101

Field-Weighted Citation Impact: 51.25