Coronary-Artery Vasoconstriction Induced by Cocaine, Cigarette Smoking, or Both

1994276 citationsJournal Articlebronze Open Access

Authors

David J. Moliterno · The University of Texas Southwestern Medical Center

John E. Willard · The University of Texas Southwestern Medical Center

Richard A. Lange · The University of Texas Southwestern Medical Center

Brian H. Negus · The University of Texas Southwestern Medical Center

James D. Boehrer · The University of Texas Southwestern Medical Center

D.Brent Glamann · The University of Texas Southwestern Medical Center

Abstract

The deleterious effects of cocaine on myocardial oxygen supply and demand are exacerbated by concomitant cigarette smoking. This combination substantially increases the metabolic requirement of the heart for oxygen but simultaneously decreases the diameter of diseased coronary arterial segments.

Topics & Keywords

Forensic Toxicology and Drug Analysis Cardiac Imaging and Diagnostics Heart Rate Variability and Autonomic Control

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 330, Issue 7, pp. 454-459

DOI: 10.1056/nejm199402173300702

Field-Weighted Citation Impact: 18.98