Single amino acid substitution Gly186Val in AdeS restores tigecycline susceptibility of<i>Acinetobacter baumannii</i>

201635 citationsJournal Articlebronze Open Access

Authors

Jun‐Ren Sun · Tri-Service General Hospital

W.Y. Jeng · National Cheng Kung University

Cherng-Lih Perng · National Defense Medical Center

Ya-Sung Yang · National Defense Medical Center

Po-Chi Soo · Tzu Chi University

Yen-Sen Chiang · National Defense Medical Center

Tzong-Shi Chiueh ·

Abstract

Our result demonstrates that a critical amino acid substitution in AdeS alters the AdeABC efflux pump-mediated tigecycline resistance of A. baumannii.

Topics & Keywords

Antibiotic Resistance in Bacteria Antibiotics Pharmacokinetics and Efficacy Berberine and alkaloids research

Publication Details

Published in: Journal of Antimicrobial Chemotherapy

Volume 71, Issue 6, pp. 1488-1492

DOI: 10.1093/jac/dkw002

Field-Weighted Citation Impact: 1.40

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Single amino acid substitution Gly186Val in AdeS restores tigecycline susceptibility of<i>Acinetobacter baumannii</i>

Authors

Abstract

Topics & Keywords

Publication Details