Prediction of conversion from mild cognitive impairment to dementia with neuronally derived blood exosome protein profile

2016381 citationsJournal Articlegold Open Access

Authors

Charisse N. Winston · University of California, San Diego

Edward J. Goetzl · Jewish Home

Johnny Akers · University of California, San Diego

Bob S. Carter · University of California, San Diego

Edward Rockenstein · University of California, San Diego

Douglas Galasko · University of California, San Diego

Eliezer Masliah

Abstract

Abnormal plasma NDE levels of P-tau, Aβ1-42, NRGN, and REST accurately predict conversion of MCI to AD dementia. Plasma NDEs from demented patients seeded tau aggregation and induced AD-like neuropathology in normal mouse CNS.

Topics & Keywords

Extracellular vesicles in disease Alzheimer's disease research and treatments MicroRNA in disease regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Volume 3, Issue 1, pp. 63-72

DOI: 10.1016/j.dadm.2016.04.001

Field-Weighted Citation Impact: 16.01