Tumour-specific delivery of siRNA-coupled superparamagnetic iron oxide nanoparticles, targeted against PLK1, stops progression of pancreatic cancer

201695 citationsJournal Articlehybrid Open Access

Authors

Ujjwal Mukund Mahajan · Moritz Klinik

Steffen Teller · Universität Greifswald

Matthias Sendler · Universität Greifswald

Raghavendra Palankar · Center for Innovation

Cindy van den Brandt · Universität Greifswald

Theresa Schwaiger · Moritz Klinik

Jens‐Peter Kühn ·

Abstract

Our data suggest siPLK1-StAv-SPIONs with dual specificity residues for tumour targeting and membrane translocation to represent an exciting opportunity for targeted therapy in patients with PDAC.

Topics & Keywords

RNA Interference and Gene Delivery Advanced biosensing and bioanalysis techniques Nanoparticle-Based Drug Delivery

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gut

Volume 65, Issue 11, pp. 1838-1849

DOI: 10.1136/gutjnl-2016-311393

Field-Weighted Citation Impact: 5.40