Virucidal Activity of Disinfectants against Parvoviruses and Reference Viruses

Some virus species can resist surprisingly harsh environmental conditions, being able to survive on surfaces for long periods and often presenting high resistance to disinfection. Viruses can be transmitted to susceptible hosts via these contaminated surfaces. This is a major concern not only in healthcare and research but also in manufacturing settings, with recent occurrences reporting viral contamination of non-human cells used to produce therapeutic enzymes in bioreactors. Consequently, a need to validate the virucidal efficacy of products used to clean and decontaminate surfaces in these facilities exists. In this study we tested two alkaline cleaners (CIP-100 and ProKlenz-One), two liquid disinfectants (SporKlenz and a peracetic-based formulation), and a gaseous hydrogen peroxide-based aerial decontamination process for their capacity to inactivate several viruses, including parvoviruses in the presence of organic soils. We demonstrate that these decontamination methods offer virucidal efficacy and can consequently ensure a very high level of protection against viral contamination.