Renal and Skeletal Lesions in Experimental Cadmium Poisoning

1974151 citationsJournal Article

Authors

Yoshinori Itokawa · Doshisha Women's College of Liberal Arts

Tomoko Abe · Doshisha Women's College of Liberal Arts

Ryo Tabei · Doshisha Women's College of Liberal Arts

Seisuke Tanaka · Doshisha Women's College of Liberal Arts

Abstract

Male Wistar rats were separated into four groups and given four different dietary regimens. After 120 days, the rats were killed and examined histologically and biochemically. Remarkable abnormalities were observed in kidneys and femurs in cadmium treated rats. Renal hypertrophy and degenerative changes in tubules and glomeruli were evident. In femurs, thinning of cortical osseous tissue, decrease in osteocytes, decrease in acid mucopolysaccharides in epiphyseal cartilage, and appearance of osteoid plus fat deposition in bone marrow were significant in calcium-deficient cadmium- treated rats.

Topics & Keywords

Drug-Induced Hepatotoxicity and Protection Heavy Metal Exposure and Toxicity Trace Elements in Health

Publication Details

Published in: Archives of Environmental Health An International Journal

Volume 28, Issue 3, pp. 149-154

DOI: 10.1080/00039896.1974.10666456

Field-Weighted Citation Impact: 4.78

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Renal and Skeletal Lesions in Experimental Cadmium Poisoning

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Abstract

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Publication Details