PFN2, a novel marker of unfavorable prognosis, is a potential therapeutic target involved in esophageal squamous cell carcinoma

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Authors

Xiaobin Cui · Shihezi University

Shumao Zhang · Shihezi University

Yuexun Xu · Zhengzhou People's Hospital

Hongwei Dang · Shihezi University

Chunxia Liu · Shihezi University

Lianghai Wang · Shihezi University

Lan Yang · Shihezi University

Abstract

Our findings demonstrate that PFN2 has a novel role in promoting ESCC progression and metastasis and portending a poor prognosis, indicating that PFN2 could act as an early biomarker of high-risk population. Targeting PFN2 may offer a promising therapeutic strategy for ESCC treatment.

Topics & Keywords

Esophageal Cancer Research and Treatment Lung Cancer Treatments and Mutations RNA modifications and cancer

UN Sustainable Development Goals

No poverty

Publication Details

Published in: Journal of Translational Medicine

Volume 14, Issue 1, pp. 137-137

DOI: 10.1186/s12967-016-0884-y

Field-Weighted Citation Impact: 5.96