Premature coronary artery disease: role of free radical nitric oxide.

Increased NO production was present in the plasma of patients with premature coronary artery disease individuals as compared to normal controls. Since NO seems to have a role in tissue damage, high concentrations of NO could have probably given rise to the said clinical manifestations. Further studies are needed in this context as to whether the changed lifestyles in the young individuals or the type of occupation is leading to the oxidative stress and thereby to the disease.