Evaluation of the 4-Pyridinemethanol WR 180,409 (Enpiroline) in the Treatment of Induced Plasmodium Falciparum Infections in Healthy, Non-Immune Subjects

WR 180,409 (enpiroline) was administered to 22 non-immune subjects infected with the multi-drug resistant Vietnam Smith isolate of Plasmodium falciparum. It was curative in single day treatment regimens with a minimum curative dose of approximately 10 mg/kg body weight. At this dose level it was well tolerated and produced rapid clearance of parasitemia in every case.