Intelligent Albumin–MnO2 Nanoparticles as pH‐/H2O2‐Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy

20161,027 citationsJournal Article

Authors

Qian Chen · Soochow University

Liangzhu Feng · Soochow University

Jingjing Liu · Soochow University

Wenwen Zhu · Soochow University

Ziliang Dong · Soochow University

Yifan Wu · Soochow University

Zhuang Liu · Soochow University

Abstract

A unique type of pH/H2 O2 dual-responsive intelligent nanoscale delivery system based on albumin-coated MnO2 is presented, which is capable of modulating the tumor microenvironment (TME) by relieving hypoxia. Additionally, TME-responsive size changes enable effective intratumor diffusion. A highly effective combined photodynamic and chemotherapy is realized with these nanoparticles in a mouse tumor model.

Topics & Keywords

Nanoplatforms for cancer theranostics Cancer, Hypoxia, and Metabolism Nanoparticle-Based Drug Delivery

Publication Details

Published in: Advanced Materials

Volume 28, Issue 33, pp. 7129-7136

DOI: 10.1002/adma.201601902

Field-Weighted Citation Impact: 61.92

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Intelligent Albumin–MnO<sub>2</sub> Nanoparticles as pH‐/H<sub>2</sub>O<sub>2</sub>‐Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy

Authors

Abstract

Topics & Keywords

Publication Details