Enabling low cost biopharmaceuticals: high level interferon alpha-2b production in Trichoderma reesei

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Authors

Christopher P. Landowski · VTT Technical Research Centre of Finland

Eero Mustalahti · VTT Technical Research Centre of Finland

Ramon Wahl · Novartis (Switzerland)

Laurence Croute · Novartis (Switzerland)

Dhinakaran Sivasiddarthan · VTT Technical Research Centre of Finland

Ann Westerholm‐Parvinen · VTT Technical Research Centre of Finland

Benjamin Sommer

Abstract

High levels of IFNα-2b were produced using T. reesei strains with reduced protease secretion. Further strain development can be done to improve the production system by reducing protease activity and improving carrier protein cleavage.

Topics & Keywords

Viral Infectious Diseases and Gene Expression in Insects Monoclonal and Polyclonal Antibodies Research Fungal and yeast genetics research

Publication Details

Published in: Microbial Cell Factories

Volume 15, Issue 1, pp. 104-104

DOI: 10.1186/s12934-016-0508-5

Field-Weighted Citation Impact: 2.09

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Enabling low cost biopharmaceuticals: high level interferon alpha-2b production in Trichoderma reesei

Authors

Abstract

Topics & Keywords

Publication Details