Diet-Gene Interplay: An Insight into the Association of Diet and FADS Gene Polymorphisms

Fatty acid desaturases (FADS) gene polymorphisms have been implicated in cardiovascular diseases, allergies, psychiatric disorders as well as the metabolic syndrome. The relationship of genetic variation and diet is complex. Recent studies have confirmed that polymorphisms in the FADS1 and FADS2 genes are associated with fatty acid compositions which may eventually influence disease susceptibility. Dietary intake of long chain polyunsaturated fatty acids (LC-PUFAs) has been studied to influence the effects of FADS gene polymorphisms. In this review, we give an insight of the diet-gene interaction with respect to FADS gene polymorphisms.