Allergen-Induced Asthmatic Responses Modified by a GATA3-Specific DNAzyme

2015315 citationsJournal Articlebronze Open Access

Authors

Norbert Krug · Fraunhofer Institute for Toxicology and Experimental Medicine

Jens M. Hohlfeld · Fraunhofer Institute for Toxicology and Experimental Medicine

Anne‐Marie Kirsten · LungenClinic Grosshansdorf

Oliver Kornmann

Kai Michael Beeh · Respiratory Research Institute

Dominik Kappeler · Inamed

Stephanie Korn · Johannes Gutenberg University Mainz

Abstract

Treatment with SB010 significantly attenuated both late and early asthmatic responses after allergen provocation in patients with allergic asthma. Biomarker analysis showed an attenuation of Th2-regulated inflammatory responses. (Funded by Sterna Biologicals and the German Federal Ministry of Education and Research; ClinicalTrials.gov number, NCT01743768.).

Topics & Keywords

Asthma and respiratory diseases Antimicrobial Peptides and Activities Advanced biosensing and bioanalysis techniques

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 372, Issue 21, pp. 1987-1995

DOI: 10.1056/nejmoa1411776

Field-Weighted Citation Impact: 29.53