Expression of RXFP1 Is Decreased in Idiopathic Pulmonary Fibrosis: Implications for Relaxin-based Therapies

201669 citationsJournal Article

Authors

Jiangning Tan · Pulmonary and Allergy Associates

John Tedrow · Pulmonary and Allergy Associates

Justin A. Dutta · Pulmonary and Allergy Associates

Brenda Juan-Guardela · Yale University

Mehdi Nouraie · Pulmonary and Allergy Associates

Yanxia Chu · Pulmonary and Allergy Associates

Humberto E. Trejo Bittar

Abstract

IPF is characterized by the loss of RXFP1 expression. RXFP1 expression is directly associated with pulmonary function in patients with IPF. The relaxin-like effects of CGEN25009 in vitro are dependent on expression of RXFP1. Our data suggest that patients with IPF with the highest RXFP1 expression would be predicted to be most sensitive to relaxin-based therapies.

Topics & Keywords

Pregnancy-related medical research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Respiratory and Critical Care Medicine

Volume 194, Issue 11, pp. 1392-1402

DOI: 10.1164/rccm.201509-1865oc

Field-Weighted Citation Impact: 6.35